Reconstructing the evolutionary history of multiple myeloma.

doi:10.1016/j.beha.2020.101145

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Article

Reconstructing the evolutionary history of multiple myeloma.

Best practice & research. Clinical haematology - 1 Mar 2020

Maura Francesco, Rustad Even H, Boyle Eileen M, Morgan Gareth J

Abstract excerpt

Multiple myeloma is the second most common lymphoproliferative disorder, characterized by aberrant expansion of monoclonal plasma cells. In the last years, thanks to novel next generation sequencing technologies, multiple myeloma has emerged as one of the most complex hematological cancers, shaped over time by the activity of multiple mutational processes and by the acquisition of key driver events. In this...

Topics

Aneuploidy
Antineoplastic Combined Chemotherapy Protocols
Chromothripsis
Evolution, Molecular
Genome, Human
High-Throughput Nucleotide Sequencing
Humans
Multiple Myeloma
Mutation
Neoplasm, Residual
Plasma Cells
Recurrence
Survival Analysis
Time Factors
Whole Genome Sequencing

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Identifiers

PMID: 32139011
DOI: 10.1016/j.beha.2020.101145
PMCID: PMC7389821

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