Article

Revealing the impact of recurrent and rare structural variants in multiple myeloma

2019-12-19

Abstract excerpt

<h4>Summary</h4> The landscape of structural variants (SVs) in multiple myeloma remains poorly understood. Here, we performed comprehensive classification and analysis of SVs in multiple myeloma, interrogating a large cohort of 762 patients with whole genome and RNA sequencing. We identified 100 SV hotspots involving 31 new candidate driver genes, including drug targets BCMA ( TNFRSF17 ) and SLAMF7 . Complex SV...

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Literature Corpus work: d61ff4fd-af37-5ddc-8173-ec4bfefd1837
DOI: 10.1101/2019.12.18.881086

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