Clonal Evolution of Multiple Myeloma—Clinical and Diagnostic Implications

doi:10.3390/diagnostics11091534

Article

Clonal Evolution of Multiple Myeloma—Clinical and Diagnostic Implications

25 Aug 2021

Abstract excerpt

Plasma cell dyscrasias are a heterogeneous group of diseases characterized by the expansion of bone marrow plasma cells. Malignant transformation of plasma cells depends on the continuity of events resulting in a sequence of well-defined disease stages, from monoclonal gammopathy of undetermined significance (MGUS) through smoldering myeloma (SMM) to symptomatic multiple myeloma (MM). Evolution of a pre-malignant...

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