Programming large target genomic deletion and concurrent insertion via a prime editing-based method: PEDAR

Abstract excerpt

Genomic insertions, duplications, and insertion/deletions (indels) account for ~14% of human pathogenic mutations. Current gene editing methods cannot accurately or efficiently correct these abnormal genomic rearrangements, especially larger alterations (>100 bp). Thus, developing a method to accurately delete insertions/duplications and repair the deletion junction could improve the scope of gene therapies. Here,...

Topics

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• CRISPR-Associated Protein 9
• CRISPR-Cas Systems
• Gene Editing
• Genetic Therapy
• Mammals
• Mutation
• Phenotype
• Zebrafish

Identifiers and source

Literature Corpus work

b65722f1-caa3-5552-bfb3-ba6fdaf55174

DOI

10.1101/2021.05.12.443800