Article

Improved split prime editors enable efficient in vivo genome editing

2024-11-05

Abstract excerpt

<h4>ABSTRACT</h4> Prime editor (PE) is a precise genome-editing tool that enables all 12 possible base-to-base conversions, as well as insertions and deletions, that does not require DSBs or donor DNA. The efficient delivery of prime editors in vivo is critical for realizing the full potential of prime editing in disease modeling and therapeutic correction. Although PE has been divided into two halves and deliver...

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Literature Corpus work: 246c5750-8c5c-5d76-8624-b2480e4fd032
DOI: 10.1101/2024.11.05.622013

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