Article

Archaic humans have contributed to large-scale variation in modern human T cell receptor genes

2022-08-25

Abstract excerpt

The human T cell receptor (TCR) genes are critical for mediating immune responses to pathogens, tumors and regulating self-antigen recognition. A detailed analysis and validation of expressed TCR alpha, beta, gamma, and delta genes in 45 donors from 4 human populations: African, East Asian, South Asian, and European, revealed a total of 175 novel TCR variable and junctional alleles. The majority of novel alleles c...

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Literature Corpus work: 2f5bf6d9-38d2-53fb-bb51-71d1a632c220
DOI: 10.1101/2022.08.25.505097

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