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Article

Proteome-wide analysis of human disease mutations in short linear motifs: neglected players in cancer?

Molecular bioSystems - 1 Oct 2014

Uyar Bora, Weatheritt Robert J, Dinkel Holger, Davey Norman E, Gibson Toby J

Abstract excerpt

Disease mutations are traditionally thought to impair protein functionality by disrupting the folded globular structure of proteins. However, 22% of human disease mutations occur in natively unstructured segments of proteins known as intrinsically disordered regions (IDRs). This therefore implicates defective IDR functionality in various human diseases including cancer. The functionality of IDRs is partly...

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PMID: 25057855
DOI: 10.1039/c4mb00290c
PMCID: PMC4306509

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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