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Article

Mutations of Intrinsically Disordered Protein Regions Can Drive Cancer but Lack Therapeutic Strategies.

Biomolecules - 4 Mar 2021

Mészáros Bálint, Hajdu-Soltész Borbála, Zeke András, Dosztányi Zsuzsanna

Abstract excerpt

Many proteins contain intrinsically disordered regions (IDRs) which carry out important functions without relying on a single well-defined conformation. IDRs are increasingly recognized as critical elements of regulatory networks and have been also associated with cancer. However, it is unknown whether mutations targeting IDRs represent a distinct class of driver events associated with specific molecular and...

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PMID: 33806614
DOI: 10.3390/biom11030381
PMCID: PMC8000335

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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