Article
Pan-cancer assessment of mutational landscape in intrinsically disordered hotspots reveals potential driver genes.
Nucleic acids research - 20 May 2022
Zou Haozhe, Pan Tao, Gao Yueying, Chen Renwei, Li Si, Guo Jing, Tian Zhanyu, Xu Gang, Xu Juan, Ma Yanlin, Li Yongsheng
Abstract excerpt
Large-scale cancer genome sequencing has enabled the catalogs of somatic mutations; however, the mutational impact on intrinsically disordered protein regions (IDRs) has not been systematically investigated to date. Here, we comprehensively characterized the mutational landscapes of IDRs and found that IDRs have higher mutation frequencies across diverse cancers. We thus developed a computational method,...
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