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Article

Disease mutations in disordered regions--exception to the rule?

Molecular bioSystems - 1 Jan 2012

Vacic Vladimir, Iakoucheva Lilia M

Abstract excerpt

Intrinsically disordered proteins (IDPs) have been implicated in a number of human diseases, including cancer, diabetes, neurodegenerative and cardiovascular disorders. Although for some of these conditions molecular mechanisms are now better understood, the big picture connecting distinct structural properties and functional repertoire of IDPs to pathogenesis and disease progression is still incomplete. Recent...

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PMID: 22080206
DOI: 10.1039/c1mb05251a
PMCID: PMC3307532

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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