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Article

Is there a biological cost of protein disorder? Analysis of cancer-associated mutations.

Molecular bioSystems - 1 Jan 2012

Pajkos Mátyás, Mészáros Bálint, Simon István, Dosztányi Zsuzsanna

Abstract excerpt

As many diseases can be traced back to altered protein function, studying the effect of genetic variations at the level of proteins can provide a clue to understand how changes at the DNA level lead to various diseases. Cellular processes rely not only on proteins with well-defined structure but can also involve intrinsically disordered proteins (IDPs) that exist as highly flexible ensembles of conformations....

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Identifiers

PMID: 21918772
DOI: 10.1039/c1mb05246b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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