Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ancient Evolutionary Origin of Intrinsically Disordered Cancer Risk Regions.

Biomolecules - 28 Jul 2020

Pajkos Mátyás, Zeke András, Dosztányi Zsuzsanna

Abstract excerpt

Cancer is a heterogeneous genetic disease that alters the proper functioning of proteins involved in key regulatory processes such as cell cycle, DNA repair, survival, or apoptosis. Mutations often accumulate in hot-spots regions, highlighting critical functional modules within these proteins that need to be altered, amplified, or abolished for tumor formation. Recent evidence suggests that these mutational...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Motifs
Share to Amino Acid Sequence
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Duplication

Share to Intrinsically Disordered Proteins

Share to Neoplasms

Share to Protein Conformation

Share to Protein Domains

Source

Open in PubMed Open full text

Identifiers

PMID: 32731489
DOI: 10.3390/biom10081115
PMCID: PMC7465906

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ancient Evolutionary Origin of Intrinsically Disordered Cancer Risk Regions.PMID 32731489Read ↗

Ancient evolutionary origin of intrinsically disordered cancer risk regionsSemantic proximity Read ↗

How mutations of intrinsically disordered protein regions can drive cancerSemantic proximity Read ↗

Mutations of Intrinsically Disordered Protein Regions Can Drive Cancer but Lack Therapeutic Strategies.Semantic proximity Read ↗

Disordered but Different: Functional and Evolutionary Divergence of Transcription Factor Intrinsically Disordered RegionsSemantic proximity Read ↗

A Functional Map of the Human Intrinsically Disordered ProteomeSemantic proximity Read ↗

Evolutionary forces on different flavors of intrinsic disorder in the human proteomeSemantic proximity Read ↗

Pan-cancer assessment of mutational landscape in intrinsically disordered hotspots reveals potential driver genes.Semantic proximity Read ↗

Is there a biological cost of protein disorder? Analysis of cancer-associated mutations.Semantic proximity Read ↗

Mutations in disordered proteins as early indicators of nucleic acid changes triggering speciationSemantic proximity Read ↗

Systematic characterization of pan-cancer mutation clusters.Semantic proximity Read ↗

Disentangling the CHAOS of intrinsic disorder in human proteinsSemantic proximity Read ↗

Conservation and coevolution determine evolvability of different classes of disordered residues in human intrinsically disordered proteins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.