Article

Ancient evolutionary origin of intrinsically disordered cancer risk regions

2020-06-15

Abstract excerpt

Cancer is a heterogeneous genetic disease that alters the proper functioning of proteins involved in key regulatory processes such as cell cycle, DNA repair, survival or apoptosis. Mutations often accumulate in hot-spots regions, highlighting critical functional modules within these proteins that need to be altered, amplified or abolished for tumor formation. Recent evidence suggests that these mutational hotspots...

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Literature Corpus work: bf30585e-b5df-5901-b952-e859ab4c5fde
DOI: 10.1101/2020.06.15.152298

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