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Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent TYROBP-APOE link in wild-type and Alzheimer’s-related mice

2020-08-19

Abstract excerpt

<h4>ABSTRACT</h4> Microglial TYROBP (also known as DAP12) has been identified by computational transcriptomics as a network hub and driver in late-onset sporadic Alzheimer’s disease (AD) and as an important regulator of the microglial environmental sensing function. TYROBP is the transmembrane adaptor of AD-related receptors TREM2 and CR3, but importantly, TYROBP interacts with many other receptors, and little is...

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Literature Corpus work
be3e7b30-9ad5-5da8-8ff1-bb61d9463182
DOI
10.1101/2020.08.18.254649
Open publication

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Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent TYROBP-APOE link in wild-type and Alzheimer’s-related miceDOI 10.1101/2020.08.18.254649
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