Article

Deletion of the microglial transmembrane immune signaling adaptor TYROBP ameliorates Huntington’s disease mouse phenotype

2022-02-19

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Huntington’s disease (HD) is a fatal neurodegenerative disorder caused by an expansion of the CAG trinucleotide repeat in the huntingtin gene. Immune activation is abundant in the striatum of HD patients. Detection of active microglia at presymptomatic stages suggests that microgliosis is a key early driver of neuronal dysfunction and degeneration. Recent studies showed that...

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Literature Corpus work: 7bb1aab9-2d53-52f3-9292-6dc95f61747a
DOI: 10.1101/2022.02.18.480944

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Deletion of the microglial transmembrane immune signaling adaptor TYROBP ameliorates Huntington’s disease mouse phenotypeDOI 10.1101/2022.02.18.480944Read

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