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Article

Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology.

Acta neuropathologica - 1 Nov 2017

Haure-Mirande Jean-Vianney, Audrain Mickael, Fanutza Tomas, Kim Soong Ho, Klein William L, Glabe Charles, Readhead Ben, Dudley Joel T, Blitzer Robert D, Wang Minghui, Zhang Bin, Schadt Eric E, Gandy Sam, Ehrlich Michelle E

Abstract excerpt

Conventional genetic approaches and computational strategies have converged on immune-inflammatory pathways as key events in the pathogenesis of late onset sporadic Alzheimer's disease (LOAD). Mutations and/or differential expression of microglial specific receptors such as TREM2, CD33, and CR3 have been associated with strong increased risk for developing Alzheimer's disease (AD). DAP12 (DNAX-activating protein...

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Share to Adaptor Proteins, Signal Transducing
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28612290
DOI: 10.1007/s00401-017-1737-3
PMCID: PMC5645450

Genes

TYROBP
APP
PSEN1
TREM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer's pathology.PMID 28612290Read ↗

Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent TYROBP-APOE link in wild-type and Alzheimer’s-related miceSemantic proximity Read ↗

Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden.Semantic proximity Read ↗

Integrative approach to sporadic Alzheimer's disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau.Semantic proximity Read ↗

Integrated biology approach reveals molecular and pathological interactions among Alzheimer’s Aβ42, Tau, TREM2, and TYROBP in Drosophila modelsSemantic proximity Read ↗

Monoallelic TYROBP deletion is a novel risk factor for Alzheimer's disease.Semantic proximity Read ↗

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