Article

Profilin 1 Controls a Microglial Cytoskeleton Checkpoint to Prevent Senescence and Premature Synaptic Decline

2025-08-27

Abstract excerpt

<title>Abstract</title> <p>Profilin 1 (Pfn1) expression decreases significantly in aged human microglia, suggesting that loss of cytoskeletal integrity may trigger microglial senescence and increased synaptic vulnerability. To test this hypothesis, we used an inducible, microglia-specific Pfn1 knockout in adult mice, a strategy designed to isolate the direct effects of acute Pfn1 loss at the cellular and circuit...

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Literature Corpus work: be23f896-8319-5f6d-ba43-ee93b5efefe5
DOI: 10.21203/rs.3.rs-6666431/v1

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