Article

Disrupted glial-mediated synaptic refinement in Fragile X syndrome

2026-04-11

Abstract excerpt

<h4>ABSTRACT</h4> Fragile X syndrome (FXS), the most common inherited cause of intellectual disability and autism, results from the loss of the RNA-binding protein fragile X mental retardation protein (FMRP). FMRP is a translational regulator and is highly expressed in glial cells, where its role in neural circuit development remains poorly defined. Here, it was observed that Fmr1 knockout mice exhibit reduced s...

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Literature Corpus work: 1d5cd208-5b53-5d59-aef7-e8d5082c9549
DOI: 10.64898/2026.04.10.717772

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