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Article

Model of selective neurodegeneration driven by a Ccp1 mutation leads to atypical microglia with an increased response to pathological stimuli.

Brain, behavior, and immunity - 1 Mar 2026

Pérez-Boyero David, de la Mata Ana, Castillo-Sanchez Jesus, Reverte Ingrid, Yanguas-Casás Natalia, Ávila-Zarza Carmelo, Valero Jorge, Alonso José R, Arevalo Maria-Angeles, Ragozzino Davide, Weruaga Eduardo, Díaz David

Abstract excerpt

Microglia are the primary immune cells of the central nervous system and maintain tissue homeostasis through phagocytosis and regulation of inflammatory signalling. Although these functions are well established, the molecular mechanisms that control microglial activation during neurodegeneration remain poorly understood. We focused on the Purkinje Cell Degeneration (PCD) mouse, which carries a loss-of-function...

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Identifiers

PMID: 41475674
DOI: 10.1016/j.bbi.2025.106248

Genes

CSF1R

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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