Article

Single-cell multiomics reveals microglia–neuron granulin signaling associated with brain aging

2026-05-04

Abstract excerpt

<title>Abstract</title> <p>Aging is the primary risk factor for neurodegenerative diseases, including limbic-predominant age-related TDP-43 encephalopathy (LATE). Although recent single-cell studies provided insights into cellular heterogeneity in the aging brain, how aging reshapes regulatory programs and intercellular communication in brain remains limited. Here, we performed an integrated single-cell multiomic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ab5853a6-4cbb-564d-8c23-2f1bb97b4892
DOI: 10.21203/rs.3.rs-9134976/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell multiomics reveals microglia–neuron granulin signaling associated with brain agingDOI 10.21203/rs.3.rs-9134976/v1Read

Single nucleus RNA-sequencing study revealed expansion of Gpnmb+ microglia in aged mouse spinal cordSemantic proximity Read

Single-cell and nucleus RNA-seq in a mouse model of AD reveal activation of distinct glial subpopulations in the presence of plaques and tanglesSemantic proximity Read

Next generation transcriptomics and genomics elucidate biological complexity of microglia in health and diseaseSemantic proximity Read

Cell-type specific molecular signatures of aging revealed in a brain-wide transcriptomic cell-type atlasSemantic proximity Read

Comprehensive single cell profiling of ageing glial cells reveals impaired Wnt signalling and Jun transcription factors regulating cortical astrocytesSemantic proximity Read

High-Dimensional Single-Cell Analysis Reveals Coordinated Age-Dependent Neuroinflammatory Microglia-T cell Circuits in the BrainSemantic proximity Read

A single-cell transcriptome atlas of cell diversity in human prefrontal cortex across the postnatal lifespanSemantic proximity Read

A transcriptomic atlas of aged human microgliaSemantic proximity Read

A global view of aging and Alzheimer’s pathogenesis-associated cell population dynamics and molecular signatures in the human and mouse brainsSemantic proximity Read

A Meta-Analysis of Microglial Heterogeneity and Gene Coexpression Networks in Aging and NeurodegenerationSemantic proximity Read

Unveiling microglial heterogeneity from single-cell transcriptomics in neurodegenerative diseasesSemantic proximity Read

Epigenetic and 3D genome reprogramming during the aging of human hippocampusSemantic proximity Read