Article

Altered synaptic connectivity and brain function in mice lacking microglial adapter protein Iba1

2021-04-23

Abstract excerpt

Growing evidence indicates that microglia impact brain function by regulating synaptic pruning and formation, as well as synaptic transmission and plasticity. Iba1 (Ionized Ca +2 -binding adapter protein 1), encoded by the Allograft inflammatory factor 1 ( Aif1 ) gene, is an actin-interacting protein in microglia. Although Iba1 has long been used as a cellular marker for microglia, its functional role remains u...

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Literature Corpus work: b1d4db93-f488-5af5-85b5-3e2bd82afbe8
DOI: 10.1101/2021.04.23.441023

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