Article
Age-related LRRK2 G2019S Mutation Impacts Microglial Dopaminergic Fiber Refinement and Synaptic Pruning Involved in Abnormal Behaviors.
Journal of molecular neuroscience : MN - 1 Mar 2022
Zhang Qiuyang, Cheng Xiaojuan, Wu Wei, Yang Siyu, You Hanlin, Ye Zucheng, Liu Nan, Chen Xiaochun, Pan Xiaodong
Abstract excerpt
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most frequent cause of autosomal dominant Parkinson's disease (PD), producing psychiatric and motor symptoms. We conducted this study to explore whether microglial dopaminergic (DAergic) fiber refinement and synaptic pruning are involved in the abnormal behavioral phenotypes of carriers of the LRRK2 G2019S mutation, by employing young and...
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