Article

Deficiency of actin depolymerizing factors ADF/Cfl1 in microglia decreases motility and impairs memory

2024-09-29

Abstract excerpt

Microglia are highly motile cells that play a crucial role in the central nervous system in health and disease. Here we show that actin depolymerizing factors ADF and Cofilin1 (Cfl1) are key factors of microglia integrity and function. We found a profound morphological phenotype in absence of ADF and Cfl1 in microglia. In vivo two-photon imaging of microglia with ADF/Cfl1-KO revealed reduced microglial fine proce...

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Literature Corpus work: 836ce85a-2b36-5a72-95d0-bd3cefced256
DOI: 10.1101/2024.09.27.615114

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