Article

Mouse-to-human modeling of microglia single-nuclei transcriptomics identifies immune signaling pathways and potential therapeutic candidates associated with Alzheimer’s disease

2025-02-08

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by memory loss and behavior change. Studies have found that dysregulation of microglial cells is pivotal to AD pathology. These mechanisms have been studied in mouse models to uncover potential therapeutic biomarkers. Despite these findings, there are limitations to the translatable biological information from mice...

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Literature Corpus work: bdff1eb2-263f-578c-bd0f-dd8ff921104f
DOI: 10.1101/2025.02.07.637100

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