Article

Cell-Type-Resolved Pseudobulk Classification Across Independent Cohorts Identifies Microglial PTPRG as a Transcriptional Hub in Alzheimer’s Disease

2026-04-10

Abstract excerpt

<h4>ABSTRACT</h4> Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and widespread cerebral pathology. Understanding cell-type-specific molecular mechanisms underlying AD is critical for identifying precise therapeutic targets. We applied a supervised machine learning approach to single-nucleus RNA sequencing data from the ROSMAP cohort, aggregating gene expre...

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Literature Corpus work: d78fbe7b-ba9f-5b92-adb2-0258952a960f
DOI: 10.64898/2026.04.07.717029

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