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Spatial transcriptomic brain imaging reveals the effects of immunomodulation therapy upon specific regional brain cells in mouse dementia model

2023-01-20

Abstract excerpt

Increasing evidence of brain-immune crosstalk raises expectations for the efficacy of novel immunotherapies in Alzheimer’s disease (AD), but the lack of methods to understand brain tissues make it difficult to examine therapeutics. Here, we investigated the changes of spatial transcriptomic signatures and brain cell type using the 10x Genomics Visium platform in immune modulated AD models by various treatments. To...

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Literature Corpus work
bf6fd0c1-a94e-5efb-99ad-e989b4b5ba02
DOI
10.1101/2023.01.20.524845
Open publication

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Spatial transcriptomic brain imaging reveals the effects of immunomodulation therapy upon specific regional brain cells in mouse dementia modelDOI 10.1101/2023.01.20.524845
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