Article

Cross-Species Translation Enhances the Use of Mouse Models for Translatability and Drug Discovery in Late-Onset Alzheimer’s Disease

2026-03-24

Abstract excerpt

Alzheimer’s disease (AD) is a brain disease characterized by deposition of insoluble amyloid-β plaque, intraneuronal neurofibrillary tangles, and cognitive dysfunction. AD can be characterized as early-onset or late-onset based on age and genetic factors. For early-onset, these genetic factors can include amyloid precursor protein (APP), presenilin-1 (PSEN1), and presenilin-2 (PSEN2). For late-onset, these can inc...

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Literature Corpus work: f417ca3b-3959-5279-9bea-d3f31df280a9
DOI: 10.64898/2026.03.21.713391

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