Article

Genome-wide single-molecule analysis of long-read DNA methylation reveals heterogeneous patterns at heterochromatin

2022-11-16

Abstract excerpt

High-throughput sequencing technology is central to our current understanding of the human methylome. The vast majority of studies use chemical conversion to analyse bulk-level patterns of DNA methylation across the genome from a population of cells. While this technology has been used to probe single-molecule methylation patterns, such analyses are limited to short reads of a few hundred basepairs. DNA methylatio...

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Literature Corpus work: bddd7da5-a9eb-5e8b-82c1-9d007cedb471
DOI: 10.1101/2022.11.15.516549

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