Article

Genome-wide epigenetic profiling of 5-hydroxymethylcytosine by long-read optical mapping

2018-02-05

Abstract excerpt

The epigenetic mark 5-hydroxymethylcytosine (5-hmC) is a distinct product of active enzymatic demethylation that is linked to gene regulation, development and disease. Genome-wide 5-hmC profiles generated by short-read next-generation sequencing are limited in providing long-range epigenetic information relevant to highly variable genomic regions, such as the 3.7 Mbp disease-related Human Leukocyte Antigen (HLA) r...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cbad7154-1919-52e5-a9d2-41cb26dc7013
DOI: 10.1101/260166

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genome-wide epigenetic profiling of 5-hydroxymethylcytosine by long-read optical mappingDOI 10.1101/260166Read

DiMeLo-seq: a long-read, single-molecule method for mapping protein-DNA interactions genome-wideSemantic proximity Read

Genome-wide single-molecule analysis of long-read DNA methylation reveals heterogeneous patterns at heterochromatinSemantic proximity Read

Epigenetic Patterns in a Complete Human GenomeSemantic proximity Read

Fine Mapping Regulatory Variants by Characterizing Native CpG Methylation with Nanopore Long-Read SequencingSemantic proximity Read

Single-cell mapping of regulatory DNA:Protein interactionsSemantic proximity Read

DNA 5-Hydroxymethylcytosines from Cell-free Circulating DNA as Diagnostic Biomarkers for Human CancersSemantic proximity Read

A Multiplexed System for Quantitative Comparisons of Chromatin Landscapes.Semantic proximity Read

Whole human genome 5’-mC methylation analysis using long read nanopore sequencingSemantic proximity Read

A Highly Sensitive and Robust Method for Genome-wide 5hmC Profiling of Rare Cell Populations.Semantic proximity Read

Global DNA methylomes reveal oncogenic-associated 5-hydroxylmethylated cytosine (5hmC) signatures in the cell-free DNA of cancer patientsSemantic proximity Read

5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stagesSemantic proximity Read

High-throughput sequencing offers new insights into 5-hydroxymethylcytosine.Semantic proximity Read