Article
Genome-scale DNA methylation analysis.
Epigenomics - 1 Feb 2010
Fouse Shaun D, Nagarajan Raman O, Costello Joseph F
Abstract excerpt
The haploid human genome contains approximately 29 million CpGs that exist in a methylated, hydroxymethylated or unmethylated state, collectively referred to as the DNA methylome. The methylation status of cytosines in CpGs and occasionally in non-CpG cytosines influences protein–DNA interactions, gene expression, and chromatin structure and stability. The degree of DNA methylation at particular loci may be...
Topics
- Bayes Theorem
- CpG Islands
- DNA Methylation
- DNA Restriction Enzymes
- Genome, Human
- Humans
- Immunoprecipitation
- Oligonucleotide Array Sequence Analysis
- Polymorphism, Single Nucleotide
- Sequence Analysis, DNA