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Fine Mapping Regulatory Variants by Characterizing Native CpG Methylation with Nanopore Long-Read Sequencing

2024-09-28

Abstract excerpt

<h4>Summary</h4> 5-methylcytosine (5mC) is the most common chemical modification occurring on the CpG sites across the human genome. Bisulfite conversion combined with short-read whole genome sequencing can capture and quantify the modification at single nucleotide resolution. However, the PCR amplification process could lead to duplicative methylation patterns and introduce 5mC detection bias. Additionally, the...

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Literature Corpus work: f0c28704-ae44-5603-84bd-b29c4a0bf524
DOI: 10.1101/2024.09.27.614715

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