Article

nanoASM: Long-Read Allele-Specific DNA Methylation Profiling Enables Functional Annotation of Regulatory Noncoding Variants in Human Prostate Tissues

2026-06-22

Abstract excerpt

<h4>Summary</h4> Long-read nanopore sequencing enables simultaneous detection of germline variation and native DNA base modifications on individual DNA molecules, providing a unique opportunity to investigate allele-specific epigenetic regulation. Here, we performed whole-genome nanopore sequencing on normal and tumor prostate tissues to characterize differential methylation, methylation entropy, and allele-speci...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 70b70fea-26d4-52c6-912e-4fe76ec95341
DOI: 10.64898/2026.06.17.732357

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

nanoASM: Long-Read Allele-Specific DNA Methylation Profiling Enables Functional Annotation of Regulatory Noncoding Variants in Human Prostate TissuesDOI 10.64898/2026.06.17.732357Read

Fine Mapping Regulatory Variants by Characterizing Native CpG Methylation with Nanopore Long-Read SequencingSemantic proximity Read

The correlation between CpG methylation and gene expression is driven by sequence variants.Semantic proximity Read

PoreMeth2: decoding the evolution of methylome alterations with Nanopore sequencingSemantic proximity Read

The Landscape of Prostate Tumour MethylationSemantic proximity Read

Allele-specific DNA methylation is increased in cancers and its dense mapping in normal plus neoplastic cells increases the yield of disease-associated regulatory SNPsSemantic proximity Read

Allele-specific DNA methylation is increased in cancers and its dense mapping in normal plus neoplastic cells increases the yield of disease-associated regulatory SNPs.Semantic proximity Read

Simultaneous profiling of chromatin accessibility and methylation on human cell lines with nanopore sequencingSemantic proximity Read

NANOME: A Nextflow pipeline for haplotype-aware allele-specific consensus DNA methylation detection by nanopore long-read sequencingSemantic proximity Read

DNA methylation calling tools for Oxford Nanopore sequencing: a survey and human epigenome-wide evaluationSemantic proximity Read

Methylome-wide Sequencing Detects DNA Hypermethylation Distinguishing Indolent from Aggressive Prostate CancerSemantic proximity Read

The 5-Hydroxymethylcytosine Landscape of Prostate CancerSemantic proximity Read

Genome-wide single-molecule analysis of long-read DNA methylation reveals heterogeneous patterns at heterochromatinSemantic proximity Read