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Differential chromatin accessibility and transcriptional dynamics define breast cancer subtypes and their lineages

30 Oct 2024

Abstract excerpt

Abstract Breast cancer (BC) is defined by distinct molecular subtypes with different cells of origin. The transcriptional networks that characterize the subtype-specific tumor-normal lineages are not established. In this work, we applied bulk, single-cell and single-nucleus multi-omic techniques as well as spatial transcriptomics and multiplex imaging on 61 samples from 37 patients with BC to show characteristic...

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PMID: 39478117
DOI: 10.1038/s43018-024-00773-6

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