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A novel subtype classification and risk of breast cancer by histone modification profiling.

Breast cancer research and treatment - 1 Jun 2016

Chen Xiaohua, Hu Hanyang, He Lin, Yu Xueyuan, Liu Xiangyu, Zhong Rong, Shu Maoguo

Abstract excerpt

Breast cancer has been classified into several intrinsic molecular subtypes on the basis of genetic and epigenetic factors. However, knowledge about histone modifications that contribute to the classification and development of biologically distinct breast cancer subtypes remains limited. Here we compared the genome-wide binding patterns of H3K4me3 and H3K27me3 between human mammary epithelial cells and three...

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PMID: 27178334
DOI: 10.1007/s10549-016-3826-8

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