Article
Analysis of Normal Human Mammary Epigenomes Reveals Cell-Specific Active Enhancer States and Associated Transcription Factor Networks.
Cell reports - 15 Nov 2016
Pellacani Davide, Bilenky Misha, Kannan Nagarajan, Heravi-Moussavi Alireza, Knapp David J H F, Gakkhar Sitanshu, Moksa Michelle, Carles Annaick, Moore Richard, Mungall Andrew J, Marra Marco A, Jones Steven J M, Aparicio Samuel, Hirst Martin, Eaves Connie J
Abstract excerpt
The normal adult human mammary gland is a continuous bilayered epithelial system. Bipotent and myoepithelial progenitors are prominent and unique components of the outer (basal) layer. The inner (luminal) layer includes both luminal-restricted progenitors and a phenotypically separable fraction that lacks progenitor activity. We now report an epigenomic comparison of these three subsets with one another, with...
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