Article

Dual-directional epi-genotoxicity assay for assessing chemically induced epigenetic effects utilizing the housekeeping TK gene

2025-01-15

Abstract excerpt

<title>Abstract</title> <p>Numerous chemicals are associated with carcinogenesis through epigenetic alterations in cells. To detect global epigenetic changes induced by carcinogens, the housekeeping gene can serve as a reporter locus, offering a baseline for identifying shifts in epigenetic marks. To investigate this potential, we developed a simple, cost-effective, and quantitative reporter system to assess chem...

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Literature Corpus work: bdc643e1-715e-5750-a753-3bb29bdff0d0
DOI: 10.21203/rs.3.rs-5623363/v1

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