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Article

Development of an integrated assay in human TK6 cells to permit comprehensive genotoxicity analysis in vitro.

Mutation research. Genetic toxicology and environmental mutagenesis - 1 Jan 2020

Smart Daniel J, Helbling Fabian R, Verardo Maëlle, Huber Alizée, McHugh Damian, Vanscheeuwijck Patrick

Abstract excerpt

In vitro genetic toxicology assays are used to assess the genotoxic potential of chemicals or mixtures. They measure chromosome damage (e.g., micronucleus [MN] formation) or gene mutation, and different combinations of data generated from such assays are evaluated in concert in order to identify genotoxic hazards. Mode-of-action (MoA) information is also fundamental to understanding any apparent genotoxic...

Topics

4-Nitroquinoline-1-oxide
Benzo(a)pyrene
Cell Line, Tumor
Cyclophosphamide
DNA
DNA Damage
Diclofenac
G2 Phase Cell Cycle Checkpoints
Gene Expression Regulation
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lymphocytes

Methyl Methanesulfonate

Micronuclei, Chromosome-Defective

Mitomycin

Mutagenesis

Mutagenicity Tests

Mutation

Thymidine Kinase

Source

Identifiers

PMID: 32087850
DOI: 10.1016/j.mrgentox.2019.503129

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-32087850-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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