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5-Aza-4’-thio-2’-deoxycytidine induces C>G transversions in a specific trinucleotide context and leads to acute lymphoid leukemia

2023-12-19

Abstract excerpt

<title>Abstract</title> <p>DNA methyltransferase inhibitors (DNMTi), most commonly cytidine analogs, are compounds that are used clinically to decrease 5’-cytosine methylation, with the aim of re-expression of tumor suppressor genes. We used a murine pre-clinical model of myelodysplastic syndrome based on transplantation of cells expressing a NUP98::HOXD13 transgene to investigate 5-Aza-4’-thio-2’-deoxycytidine (...

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Literature Corpus work
55f8b0d8-2e7e-5a90-adaa-99864468f088
DOI
10.21203/rs.3.rs-3186246/v1
Open publication

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5-Aza-4’-thio-2’-deoxycytidine induces C&gt;G transversions in a specific trinucleotide context and leads to acute lymphoid leukemiaDOI 10.21203/rs.3.rs-3186246/v1
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