Article
Follow-up genotoxicity assessment of Ames-positive/equivocal chemicals using the improved thymidine kinase gene mutation assay in DNA repair-deficient human TK6 cells.
Mutagenesis - 6 Oct 2021
Sassa Akira, Fukuda Takayuki, Ukai Akiko, Nakamura Maki, Sato Ryosuke, Fujiwara Sho, Hirota Kouji, Takeda Shunichi, Sugiyama Kei-Ichi, Honma Masamitsu, Yasui Manabu
Abstract excerpt
Genotoxicity testing plays an important role in the safety assessment of pharmaceuticals, pesticides and chemical substances. Among the guidelines for various genotoxicity tests, the in vitro genotoxicity test battery comprises the bacterial Ames test and mammalian cell assays. Several chemicals exhibit conflicting results for the bacterial Ames test and mammalian cell genotoxicity studies, which may stem from...
Topics
- Carcinogens
- Cell Line
- DNA Damage
- DNA Repair
- DNA Repair-Deficiency Disorders
- Dose-Response Relationship, Drug
- Humans
- Mutagenicity Tests
- Mutagens
- Mutation