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Article

Toxicogenomics: overview and potential applications for the study of non-covalent DNA interacting chemicals.

Mutation research - 1 Oct 2007

Li Heng-Hong, Aubrecht Jiri, Fornace Albert J

Abstract excerpt

Non-covalent DNA interacting agents, DNA-groove binding chemicals and DNA intercalators, are generally considered less cytotoxic than agents producing covalent DNA adducts and other DNA damage. Although the impact of non-covalent compound-DNA interactions on convoluted molecular and biochemical pathways is not well characterized, the most prominent effects include DNA conformational and related structural...

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PMID: 17548094
DOI: 10.1016/j.mrfmmm.2007.03.013

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