Article
Potassium bromate treatment predominantly causes large deletions, but not GC>TA transversion in human cells.
Mutation research - 1 Jun 2007
Luan Yang, Suzuki Takayoshi, Palanisamy Rajaguru, Takashima Yoshio, Sakamoto Hiroko, Sakuraba Mayumi, Koizumi Tomoko, Saito Mika, Matsufuji Hiroshi, Yamagata Kazuo, Yamaguchi Teruhide, Hayashi Makoto, Honma Masamitsu
Abstract excerpt
Potassium bromate (KBrO(3)) is strongly carcinogenic in rodents and mutagenic in bacteria and mammalian cells in vitro. The proposed genotoxic mechanism for KBrO(3) is oxidative DNA damage. KBrO(3) can generate high yields of 8-hydroxydeoxyguanosine (8OHdG) DNA adducts, which cause GC>TA transversions in cell-free systems. In this study, we investigated the in vitro genotoxicity of KBrO(3) in human lymphoblastoid...
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