Article

Lead exposure triggers DNA damage in TK6 cells via alteration of DNA repair gene expression and hypermethylation of Ku80 promoter region

2025-10-30

Abstract excerpt

<title>Abstract</title> <p> Lead (Pb) is a widespread environmental metal with recognized genotoxicity, yet whether it impairs DNA damage repair via epigenetic regulation remains unclear. Here, human lymphoblastoid TK6 cells were exposed to lead acetate at 0, 120, 240, or 480 µM for 24 h. We quantified cell viability, oxidative stress indicators (ROS, MDA, SOD, CAT), DNA damage markers (single-cell gel electroph...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7723485d-f4d2-55cb-a530-e76ed1634255
DOI: 10.21203/rs.3.rs-7836419/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Lead exposure triggers DNA damage in TK6 cells via alteration of DNA repair gene expression and hypermethylation of Ku80 promoter regionDOI 10.21203/rs.3.rs-7836419/v1Read

Impact of DNA repair polymorphisms on DNA instability biomarkers induced by lead (Pb) in workers exposed to the metal.Semantic proximity Read

Genotoxic effects of occupational exposure to lead and influence of polymorphisms in genes involved in lead toxicokinetics and in DNA repair.Semantic proximity Read

Genotoxic effects of lead: an updated review.Semantic proximity Read

Lead Exposure Induces Telomere Instability in Human CellsSemantic proximity Read

Genotoxicity effects in Cancer Patients: Evaluation by Micronucleus and Comet Assays and Correlation with Biochemical and Hematological IndicesSemantic proximity Read

Genotoxic and mutagenic properties of Ni and NiO nanoparticles investigated by comet assay, γ-H2AX staining, Hprt mutation assay and ToxTracker reporter cell lines.Semantic proximity Read

Potassium bromate treatment predominantly causes large deletions, but not GC>TA transversion in human cells.Semantic proximity Read

Uranium induces genomic instability and slows cell cycle progression in human lymphocytes in acute toxicity studySemantic proximity Read

Epigenetic modifications associated with pathophysiological effects of lead exposureSemantic proximity Read

Genotoxicity effects in Cancer Patients: Evaluation by Micronucleus and Comet Assays and Correlation with Biochemical and Hematological IndicesSemantic proximity Read

Dual-directional epi-genotoxicity assay for assessing chemically induced epigenetic effects utilizing the housekeeping TK geneSemantic proximity Read

Research progress on biodosimeters of ionizing radiation damageSemantic proximity Read