Article

APOBEC3A/B-induced mutagenesis is responsible for 20% of heritable mutations in the TpCpW context

2016-05-19

Abstract excerpt

APOBEC3A/B cytidine deaminase is responsible for the majority of cancerous mutations in a large fraction of cancer samples. However, its role in heritable mutagenesis remains very poorly understood. Recent studies have demonstrated that both in yeast and in human cancerous cells, most of APOBEC3A/B-induced mutations occur on the lagging strand during replication. Here, we use data on rare human polymorphisms, inte...

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Literature Corpus work: bdb25800-dceb-5f3c-b1c7-e37e3796ee54
DOI: 10.1101/054197

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