Article

An atlas of TF driven gene programs across human cells

2025-06-01

Abstract excerpt

Combinations of transcription factors (TFs) regulate gene expression and determine cell fate. Much effort has been devoted to understanding TF activity in different tissues and how tissue-specificity is achieved. However, ultimately gene regulation occurs at the single cell level and the recent explosion in the availability of single cell gene expression data now makes it possible to understand TF activity at this...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: bd93d8fc-7435-56f1-a254-3fe2c4f23e03
DOI: 10.1101/2025.05.30.657075

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

An atlas of TF driven gene programs across human cellsDOI 10.1101/2025.05.30.657075Read

Specifying cellular context of transcription factor regulons for exploring context-specific gene regulation programsSemantic proximity Read

Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases.Semantic proximity Read

Regulatory network hubs guide dynamic human lineage specificationSemantic proximity Read

A single-cell atlas of transcribed <i>cis</i> -regulatory elements in the human genomeSemantic proximity Read

Graph-based tracing of dynamically functioning gene circuits in cell fate decisions with isoform resolutionSemantic proximity Read

A human cell atlas of fetal gene expressionSemantic proximity Read

Chromatin and gene-regulatory dynamics of human pulmogenesis by single cell multiomic sequencingSemantic proximity Read

Genomic Architecture of Cells in Tissues (GeACT): Study of Human Mid-gestation FetusSemantic proximity Read

Epiregulon: Inference of single-cell transcription factor activity to predict drug response and drivers of cell stateSemantic proximity Read

HCNetlas: Human cell network atlas enabling cell type-resolved disease geneticsSemantic proximity Read

Shared regulation and functional relevance of local gene co-expression revealed by single cell analysisSemantic proximity Read

Single-Nucleus Atlas of Cell-Type Specific Genetic Regulation in the Human BrainSemantic proximity Read