Article

Epiregulon: Inference of single-cell transcription factor activity to predict drug response and drivers of cell state

2023-11-28

Abstract excerpt

Transcription factors (TFs) and transcriptional coregulators represent an emerging class of therapeutic targets in oncology. Gene regulatory networks (GRNs) can be used to evaluate pharmacological agents targeting these factors and to identify drivers of disease and drug resistance. However, GRN methods that rely solely on gene expression often fail to account for post-transcriptional modulation of TF function. We...

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Literature Corpus work: 59ee5c82-4da4-58c9-b291-9a612f95bb23
DOI: 10.1101/2023.11.27.568955

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