Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases.

Nature methods - 1 Apr 2016

Marbach Daniel, Lamparter David, Quon Gerald, Kellis Manolis, Kutalik Zoltán, Bergmann Sven

Abstract excerpt

Mapping perturbed molecular circuits that underlie complex diseases remains a great challenge. We developed a comprehensive resource of 394 cell type- and tissue-specific gene regulatory networks for human, each specifying the genome-wide connectivity among transcription factors, enhancers, promoters and genes. Integration with 37 genome-wide association studies (GWASs) showed that disease-associated genetic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain Diseases
Share to Cell Lineage
Share to Computational Biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epigenomics

Share to Gene Regulatory Networks

Share to Genome, Human

Share to Organ Specificity

Share to Protein Interaction Mapping

Source

Open in PubMed Open full text

Identifiers

PMID: 26950747
DOI: 10.1038/nmeth.3799
PMCID: PMC4967716

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tissue-specific regulatory circuits reveal variable modular perturbations across complex diseases.PMID 26950747Read ↗

Integrative analysis of 10,000 epigenomic maps across 800 samples for regulatory genomics and disease dissectionSemantic proximity Read ↗

Functional enrichments of disease variants across thousands of independent loci in eight diseasesSemantic proximity Read ↗

An integrative functional genomics framework for effective identification of novel regulatory variants in genome-phenome studies.Semantic proximity Read ↗

Discover novel disease-associated genes based on regulatory networks of long-range chromatin interactions.Semantic proximity Read ↗

Epigenomic regulatory programs reveal the latent heterogeneity of complex diseasesSemantic proximity Read ↗

scRiskDB: a single-cell epigenomic resource linking complex traits to regulatory mechanisms across human tissues.Semantic proximity Read ↗

Understanding Tissue-specific Gene RegulationSemantic proximity Read ↗

Enabling Precision Medicine through Integrative Network Models.Semantic proximity Read ↗

Integrating multiomic layers to decode psychiatric disease mechanisms.Semantic proximity Read ↗

An atlas of TF driven gene programs across human cellsSemantic proximity Read ↗

Disease-associated variants in different categories of disease located in distinct regulatory elements.Semantic proximity Read ↗

Single-Nucleus Atlas of Cell-Type Specific Genetic Regulation in the Human BrainSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.