Article

The Fanconi anemia pathway repairs colibactin-induced DNA interstrand cross-links

2024-01-30

Abstract excerpt

Colibactin is a secondary metabolite produced by bacteria present in the human gut and is implicated in the progression of colorectal cancer and inflammatory bowel disease. This genotoxin alkylates deoxyadenosines on opposite strands of host cell DNA to produce DNA interstrand cross-links (ICLs) that block DNA replication. While cells have evolved multiple mechanisms to resolve (“unhook”) ICLs encountered by the r...

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Literature Corpus work: bd7c0839-a4b4-5195-b701-41dc7ed259d8
DOI: 10.1101/2024.01.30.576698

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