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O6-2'-Deoxyguanosine-butylene-O6-2'-deoxyguanosine DNA Interstrand Cross-Links Are Replication-Blocking and Mutagenic DNA Lesions.

Chemical research in toxicology - 21 Nov 2016

Xu Wenyan, Kool Daniel, O'Flaherty Derek K, Keating Ashley M, Sacre Lauralicia, Egli Martin, Noronha Anne, Wilds Christopher J, Zhao Linlin

Abstract excerpt

DNA interstrand cross-links (ICLs) are cytotoxic DNA lesions derived from reactions of DNA with a number of anti-cancer reagents as well as endogenous bifunctional electrophiles. Deciphering the DNA repair mechanisms of ICLs is important for understanding the toxicity of DNA cross-linking agents and for developing effective chemotherapies. Previous research has focused on ICLs cross-linked with the N7 and N2...

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Identifiers

PMID: 27768841
DOI: 10.1021/acs.chemrestox.6b00278
PMCID: PMC5665164

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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