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Article

Probing Microbiome Genotoxicity: A Stable Colibactin Provides Insight into Structure-Activity Relationships and Facilitates Mechanism of Action Studies.

Journal of the American Chemical Society - 29 Sept 2021

Wernke Kevin M, Tirla Alina, Xue Mengzhao, Surovtseva Yulia V, Menges Fabian S, Herzon Seth B

Abstract excerpt

Colibactin is a genotoxic metabolite produced by commensal-pathogenic members of the human microbiome that possess the clb (aka pks) biosynthetic gene cluster. clb+ bacteria induce tumorigenesis in models of intestinal inflammation and have been causally linked to oncogenesis in humans. While colibactin is believed underlie these effects, it has not been possible to study the molecule directly due to its...

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PMID: 34524796
DOI: 10.1021/jacs.1c07559

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Probing Microbiome Genotoxicity: A Stable Colibactin Provides Insight into Structure-Activity Relationships and Facilitates Mechanism of Action Studies.PMID 34524796Read ↗

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