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Article

Stalled replication forks generate a distinct mutational signature in yeast.

Proceedings of the National Academy of Sciences of the United States of America - 5 Sept 2017

Larsen Nicolai B, Liberti Sascha E, Vogel Ivan, Jørgensen Signe W, Hickson Ian D, Mankouri Hocine W

Abstract excerpt

Proliferating cells acquire genome alterations during the act of DNA replication. This leads to mutation accumulation and somatic cell mosaicism in multicellular organisms, and is also implicated as an underlying cause of aging and tumorigenesis. The molecular mechanisms of DNA replication-associated genome rearrangements are poorly understood, largely due to methodological difficulties in analyzing specific...

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Identifiers

PMID: 28827358
DOI: 10.1073/pnas.1706640114
PMCID: PMC5594675

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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